Cancer

Oncology

  • First Spanish oncology service, created in the late 1970s by Jesús Vicente Fernández, who also founded the Spanish Chemotherapy Society (SEQUIO), the Spanish Society of Medical Oncology (SEOM), and the Federation of Spanish Oncology Societies, of which he was the first President.
  • First Spanish oncology service to train residents.
  • Dr. Francisco Lobo Samper (Head of Service) is an authority on lymphomas, having spent 3 years at the University of Nebraska.
  • Dr. Manuel Dómine Gómez was awarded a 3-year fellowship by the European Society for Medical Oncology (ESMO) to work at the Royal Free Hospital School of Medicine, University of London, for his project entitled "Targeted therapy of cancer and differentiation therapy".
  • Current basic and clinical research is mainly focused on individualized cancer treatment based on the genetic profile of each patient.

Infectious Diseases

Immunology

  • Immunology as a specialty was introduced in Fundación Jiménez Díaz by Dr. Fernando Ortiz, with the creation of the first Spanish immunology service in 1969.

Microbiology

  • Groundbreaking European publication that changed the way in which prosthetic infections are diagnosed, and on which the current SEIMC protocol on osteoarticular infection is based. Esteban J, Gómez-Barrena E, Cordero J, Martín-de-Hijas NZ, Kinnari TJ, Fernández-Roblas. Evaluation Of Quantitative Cultures From Sonicated Retrieved Orthopaedic Implants In The Diagnosis Of Orthopaedic Infection. Journal of Clinical Microbiology. 2008. 46 (2): 488-492.

Allergies

  • First and only service in Spain with a dynamic inhalation challenge chamber for the study of occupational asthma and a closed circuit for provocation studies with powdered substances.

Neuroscience

  • Discovery of one of the 2 genes responsible for Lafora disease; characterization of families with familial epilepsy with mutations in genes such as SN1A, CHNRB2, and Filamin A; implementation of genetic testing for Lafora disease and Dravet disease; study of sudden unexpected death in epilepsy (SUDEP) and of families with mutations in SCN1A.

Nutrition

  • Dr. Maria Luisa Villanueva-Peñacarrillo leads the group that first described the insulin-like effect of GLP-1 (glucagon-like peptide 1) on hydrocarbon, lipid, and bone metabolism in peripheral tissues in healthy individuals, and its mechanisms of action. Several important scientific studies have been published based on this finding.
  • Doctor Pedro Esbrit Argüelles is one of the top 10 experts in the world in the study of the pathophysiology of parathyroid hormone-related protein (PTH-rP) (www.biomedexperts.comThis link opens in a popup window), for which he received the 2006 award from the Iñigo Alvarez de Toledo Kidney Foundation.
  • Professor Adela Rovira Loscos has worked on the mechanism of action of insulin and the interactions of this hormone with sulfonylureas, thyroid hormones, and PPAR-gamma agonists. Her studies have led to important publications in the fields of diabetes and endocrinology and several doctoral theses.
  • Professor Mercedes Ruíz Moreno pioneered the introduction of parenteral nutrition in children and adolescents, and has conducted important research into breastfeeding and lipid metabolism, and the diagnosis and treatment of viral hepatitis in children. For her long and fruitful career in science she received the 1996 Rey Jaime I award for Research in Clinical Medicine.
  • For his research on the pathophysiological role of ghrelin peptide in children (description of expression levels from the neonatal period through to adulthood in normal and pathological situations, including obesity, anorexia, and diabetes) Professor Leandro Soriano Guillén has received significant national and international attention. This line of research has led to several publications in premier journals in the field of pediatrics.
  • Professor Pedro Mata López is known internationally for his descriptions of the effects of dietary fatty acids on lipid profiles and other processes including LDL oxidation, smooth muscle cell proliferation, and monocyte adhesion. This line of research has produced important international publications and the FDA has endorsed the beneficial effect of olive oil based on the findings of this research group. Currently, the group directed by Professor Mata is participating in the development of the world's first biochip for the detection of familial hypercholesterolemia. This finding has resulted in a Spanish patent and has been marketed as a diagnostic test.
  • The work of Dr. Carmen Garcés Segura has received particular attention for her research into the genetic determinants and environmental factors related to cardiovascular risk factors such as altered lipid levels and obesity from childhood through to adulthood. This work has resulted in several doctoral theses and publications in highly prestigious international journals.

Cardiovascular Pathology

  • Nephrology research lab of reference in Spain: integration of basic and medical researchers, over 70 doctoral theses and more than 400 publications (18 with over 100 citations), firmly established within the European research space.
  • Pioneers in the study of the proinflammatory effects of angiotensin II (Hernadez-Presa M et al. Circulation 1997, PMID 9118522, 301 citations).
  • Pathogenesis of atherosclerosis: pioneers in the study of the pleiotropic effects of statins (Guijarro C et al. Circulation Research 1998, PMID 9734471, 255 citations) and the identification of biomarkers in atherosclerosis (patented).
  • Pioneers in the study of the role of apoptosis in target organ damage in diabetes (Ortiz A et al, Journal of Investigative Medicine 1997, PMID 9084575, 103 citations).
  • Pioneers in the diagnosis and treatment of complex arrhythmias.

Genetics

  • Creation of Spain’s first Genetics Service in the FJD by Andrés Sánchez Cascos in 1962, where the first generation of Spanish clinical geneticists was trained.
  • First Spanish center to perform prenatal diagnosis by amniocentesis (1977) by chorionic villus sampling (1980) and noninvasive prenatal diagnosis (2008); pioneer in preimplantation genetic diagnosis of Huntington´s disease (2002) and inherited chromosomal abnormalities (2008).

  • Researchers of the Genetics Service have contributed to the discovery of several genes (Nature Genetics 1993, PMID 8513324; Nature Genetics 1998, PMID 9425888; Science 1998, PMID 9624053) and new genetic mechanisms (Nature Genetics 2009, PMID 19234473; Nature Genetic. 2010, PMID 20081859).
  • First clinical trials of the application of pharmacogenetic methods to clinical practice.
  • Center of reference for genetic diagnosis and advice in neurosensory diseases, mental retardation, and malformations.

Health technology and innovation

  • Use of volumetric capnography in invasive mechanical ventilation. Search for early detection strategies in lung collapse.
  • Invasive mechanical ventilation strategies in an experimental model of acute respiratory distress.
  • Management of AKI in intensive care medicine.
  • Early detection and management of dysphagia.
  • Diagnosis and treatment of HIV/AIDS-associated intestinal disorders.