A CD shall be sent to the Secretariat of the FJD Ethics Committee (Avda. Reyes Católicos, 2, 5ª planta); this must contain a letter indicating the non-material changes to be made or Appendix 1C in the case of multicenter trials, indicating that the information contained is for the ethics committee. Also, the sponsor shall send the non-material change to the different ethics committee involved; this shall be sent in the format required by each ethics committee. Lastly, the applicable bodies must be notified of the aforementioned non-material modifications.