SERRATOSA FERNANDEZ, JOSE Mª

José María Serratosa Fernández

Medico jefe de servicio de Neurología
Especialidad: Neurología
Especialidad: Neurología
Hospitales donde trabaja:
  • Hospital Universitario Fundación Jiménez Díaz
Especialidades que atiende:
Titulación
  • Licenciado en Medicina y Cirugía por la Universidad Autónoma de Madrid (1981)
  • Especialista en Neurología (1987)
  • Doctor en Medicina y Cirugía por la Universidad Autónoma de Madrid (1993)
  • Formación en epileptología en la Universidad de California de Los Ángeles (UCLA) (1989-1995)
  • Genética de las Epilepsias
  • Cirugía de la Epilepsia
  • Fármacos antiepilépticos
  • Epilepsias Mioclónicas Progresivas
  • Solaz-Fuster MC, Gimeno-Alcañiz JV, Ros S, Fernandez-Sanchez ME, Garcia-Fojeda B, Criado Garcia O, Vilchez D, Dominguez J, Garcia-Rocha M, Sanchez-Piris M, Aguado C, Knecht E, Serratosa J, . Guinovart J, Sanz P, Rodriguez de Córdoba S. Regulation of glycogen synthesis by the laforin-malin complex is modulated by the AMP-activated protein kinase pathway. Hum Mol Genet 2008;17:667-78.
  • Díaz-Otero F, Quesada M, Morales-Corraliza J, Martínez-Parra C, Gómez-Garre P, Serratosa JM.. Autosomal dominant nocturnal frontal lobe epilepsy with a mutation in the CHRNB2 gene. Epilepsia 2008;49:516-20.
  • Caicoya AG, Macarrón J, Albisua J, Serratosa JM. Tailored resections in occipital lobe epilepsy surgery guided by monitoring with subdural electrodes: characteristics and outcome. Epilepsy Res 2008;77:1-10.
  • Villanueva V, Gomez-Caigoya A, Gutierrez-Delicado E, Serratosa JM. Open-label, prospective and observational study of efficacy and tolerability with levetiracetam during one year of follow-up. Neurologia. 2007;22:348-53.
  • Gomez-Abad C, Afawi Z, Korczyn AD, Misk A, Shalev SA, Spiegel R, Lerman-Sagie T, Lev D, Kron KL, Gomez-Garre P, Serratosa JM, Berkovic SF. Founder effect with variable age at onset in arab families with Lafora disease and EPM2A mutation. Epilepsia; 2007;48:1011-4.
  • Gómez-Garre P, Gutierrez-Delicado E, Gomez-Abad C, Morales Corraliza J, Villanueva V, Larraruri J, Gutierrez M, Berciano J, Serratosa JM. Hepatic disease as the first manifestation of Lafora disease. Neurology 2007;68:1369-1373.
  • Caicoya A, Serratosa JM. Postictal behaviour in temporal lobe epilepsy. Epileptic Disord 2006;8;228-23.
  • Villanueva V, Álvarez-Linera J, Gómez-Garre P, Guitiérrez J, Serratosa JM. MRI volumetry and proton MR spectroscopy of the brain in Lafora disease. Epilepsia 2006;47:788-92.
  • Gómez-Garre P, Seijo M, Gutiérrez-Delicado E, Castro del Río M, de la Torre C, Gómez-Abad C, Morales Corraliza J, Puig M, Serratosa JM. Ehlers-Danlos Syndrome and Periventricular Nodular Heterotopia in a Spanish family with a single FLNA mutation. Journal of Medical Genetics 2006;43: 232-7 (publicado on-line el 1 de Julio de 2005).
  • Gomez-Abad C, Gomez-Garre P, Gutierrez-Delicado E, Saygi S, Michelucci R, Tassinari CA, Rodriguez de Cordoba S, Serratosa JM. Lafora disease due to EPM2B mutations: A clinical and genetic study. Neurology 2005;64:982-6.
  • Villanueva VE, Serratosa JM. Temporal lobe epilepsy: Clinical semiology and age at onset. Epileptic disorders 2005;7:83-90.
  • Salas-Puig J, Serratosa JM, Viteri C, Gil-Nagel-Rein A; Grupo Espanol del Estudio SKATE. [Safety of levetiracetam as adjunctive therapy in epilepsy: the SKATE trial in Spain] Rev Neurol. 2004;38.
  • Gil-Nagel A, Perucca E, Garcia-Morales I, Arroyo S, Serratosa JM; Subcommission on Congress Evaluation of the ILAE Commission on European Affairs. Evaluations and awards at the fifth European Congress of Epileptology, Madrid, 6-10 October 2002. Epilepsia. 2004;45.
  • Berkovic SF, Serratosa JM, Phillips HA, Xiong L, Eva Andermann E, Díaz-Otero F, Gómez-Garre P, Martín M, Fernández-Bullido Y, Andermann F, Lopes-Cendes I, Dubeau F, Desbiens R, Scheffer I, Wallace RH, Mulley JC Pandolfo M. Familial partial epilepsy with variable foci: clinical features and linkage to chromosome 22q12. Epilepsia. 2004;45:1054-1060.
  • Baulac S, Gourfinkel-An I, Nabbout R, Huberfeld G, Serratosa J, Leguern E,Baulac M. Fever, genes, and epilepsy. Lancet Neurol 2004;3:421-430.
  • Fernandez-Sanchez ME, Criado-Garcia O, Heath KE, Garcia-Fojeda B, Medrano-Fernandez I, Gomez-Garre P, Sanz P, Serratosa JM, Rodriguez De Cordoba S. Laforin, the dual-phosphatase responsible for Lafora disease, interacts with R5 (PTG), a regulatory subunit of protein phosphatase-1 that enhances glycogen accumulation. Hum Mol Genet 2003;12:3161-71.
  • Garcia-Ruiz PJ, Villanueva V, Gutierrez-Delicado E, Echeverria A, Perez-Higueras A, Serratosa JM. Subthalamic lesion and paroxysmal tonic spasms. Mov Disord 2003;18:1401-3.
  • Gutierrez-Delicado E, Serratosa JM. Genetics of the epilepsies. Curr Opin Neurol 2004;17:147-53.
  • Villanueva V, Peral E, Albisua J, De Felipe J, Serratosa JM. Factores pronósticos en cirugía del lóbulo temporal. Neurología 2004;19:92-98.
  • Sáez-Hernández L, Peral B, Sanz R, Gómez-Garre P, Ramos C, Ayuso C, Serratosa JM. Characterization of a 6p21 translocation breakpoint in a family with idiopathic generalized epilepsy. Epilepsy Research 2003;56:155-63.
  • Anderson E, Berkovic S, Dulac O, Gardiner M, Jain S, Laue-Friis M, Lindhout D, Noebels J, Ottman R, Scaramelli A, Serratosa, J, Steinlein O, Avanzini G, Bailey-Wilson J, Cardon L, Fischbach R, Gwinn-Hardy K, Leppert M, Ott J, Lindblad-Toh K, Weiss K. ILAE genetics commission conference report: molecular analysis of complex genetic epilepsies. Epilepsia. 2002;43:1262-7.
  • Martínez-Bermejo A, López Martín V, Serratosa JM, Gutiérrez-Molina M, Gómez-Garre P, Arcas J, Tendero A, Roche C, Pérez, Mies B. Lafora disease: a new case of confirmation of diagnosis on molecular genetic studies. Rev Neurol 2002;34:117-20.
  • Villanueva VE, Serratosa JM. The course of the catastrophic epilepsies. Rev Neurol. 2002;34:501-5.
  • Arroyo S, Brodie MJ, Avanzini G, Baumgartner C, Chiron C, Dulac O, French JA, Serratosa JM. Is refractory epilepsy preventable? Epilepsia 2002;43:437-44.
  • Michelucci R. Serratosa JM, Genton P, Tassinari CA. Seizures, myoclonus and cerebellar dysfunction in progressive myoclonus epilepsies. En: Guerrini R, Aicardi J, Andermann F, Hallet M, eds. Epilepsy and movement disorders. Cambridge: Cambridge University Press, 2002:227-49.
  • Serratosa JM. Myoclonic seizures. En: Wyllie E, ed. The treatment of Epilepsy: Principles and Practice. Philadelphia: Lippincott Williams and Wilkins, 2001:395-403.
  • Serratosa JM. The progressive myoclonus epilepsies. En: Wyllie E, ed. The treatment of Epilepsy: Principles and Practice. Philadelphia: Lippincott Williams and Wilkins, 2001:509-24.
  • Serratosa JM. Juvenile myoclonic epilepsy. En: Wyllie E, ed. The treatment of Epilepsy: Principles and Practice. Philadelphia: Lippincott Williams and Wilkins, 2001:491-507.
  • Gómez-Garre P, Sanz Y, Rodríguez de Córdoba S, Serratosa JM. The Mutational Spectrum of the EPM2A Gene in Progressive Myoclonus Epilepsy of Lafora: High Degree of Allelic Heterogeneity and Prevalence of Deletions. Eur J Hum Genet 2000;8:946-54.
  • Serratosa JM. La enfermedad de Lafora en los albores del Siglo XXI. Editorial. Neurología 1999;14:325-7.
  • Serratosa JM. Idiopathic epilepsies with a complex mode of inheritance. Epilepsia 1999;40 (suppl 3):12-16.
  • Serratosa JM, Gardiner RM, Lehesjoki A-E, Pennachio LA, Myers RM.The molecular genetic bases of the progressive myoclonus epilepsies. En: Delgado-Escueta A, Wilson WA, Olsen RW, Porter RJ, eds. Jasper´s basic mechanisms of the epilepsies. Philadelphia: Lippincott-Williams and Wilkins, 1999:552-70.
  • Minassian BA, Sainz J, Serratosa JM, Gee M, Sakamoto LM, Bohlega S, Geoffroy G, Barr C, Scherer SW, Tomiyasu U, Carpenter S, Wigg K, Sanghvi AV, Delgado-Escueta AV. Genetic locus heterogeneity in Lafora's progressive myoclonus epilepsy. Annals of Neurology 1999;45:262-5.
  • Serratosa JM, Pilar Gómez-Garre P, Gallardo ME, Anta B, Beltrán-Valero de Bernabé D, Lindhout, Augustijn PB, Carlo A. Tassinari CA, Roberto Michelucci R, Malafosse A, Topcu M, Grid D, Dravet C, Berkovic SF, Rodríguez de Córdoba S. A novel protein tyrosine phosphatase gene is mutated in progressive myoclonus epilepsy of the Lafora type (EPM2). Hum Mol Genet 1999;8:345-52.
  • Fong GC, Shah PU, Gee MN, Serratosa JM, Castroviejo IP, Khan S, Ravat SH, Mani J, Huang Y, Zhao HZ, Medina MT, Treiman LJ, Pineda G, Delgado-Escueta AV. Childhood absence epilepsy with tonic-clonic seizures and electroencephalogram 3-4-Hz spike and multispike-slow wave complexes: linkage to chromosome 8q24. Am J Hum Genet 1998;63:1117-29.
  • Sainz J, Minassian B, Serratosa JM, et al. Lafora´s progressive myoclonus epilepsy: narrowing the chromosome 6q24 locus by recombinations and homozigosities. American Journal of Human Genetics 1997;61:1205-9.
  • Delgado-Escueta AV, Serratosa JM. Seizures and epilepsies. En: Kelley W, ed. Textbook of Internal Medicine. Philadelphia: J.P. Lippincott, 1997:2427-36.
  • Delgado-Escueta AV, Serratosa JM. Approach to the patient with seizures and epilepsies. En: Kelley W, ed. Textbook of Internal Medicine. Philadelphia: J.P. Lippincott, 1997:2347-54.
  • Serratosa JM, Delgado-Escueta AV, Medina MT, Zhang Q, Sparkes RS. Clinical and genetic analysis of a large pedigree with juvenile myoclonic epilepsy. Annals of Neurology 1996; 39:187-195.
  • Liu AW, Delgado-Escueta AV, Gee MN, Serratosa JM, Zhang QW, Alonso ME, Medina NT, Cordova S, Zhao HZ, Spellman JM, Rubio Donnadieu F, Ramos-Peek JR, Treiman LJ, Sparkes RS. Juvenile myoclonic epilepsy locus in 6p21.2-p11: locus heterogeneity and recombinations. American Journal of Medical Genetics 1996; 63:368-381.
  • Serratosa JM, Delgado-Escueta AV. Mapping human epilepsy genes: implications for the treatment of epilepsy. CNS Drugs 1996; 5:155-159.
  • Guerrini R, De Lorey TM, Bonani P, Moncla A, Dravet C, Suisse G, Livet MO, Bureau M, Malzac P, Genton P, Thomas P, Sartucci, Simi P, Serratosa JM. Cortical myoclonus of Angelman syndrome. Annals of Neurology 1996; 39:699-708.
  • Serratosa JM, Delgado-Escueta AV, Posada I, Shih S, Drury I, Berciano J, Zabala JA, Antúnez, Sparkes RS. The gene for progressive myoclonus epilepsy of the Lafora type maps to chromosome 6q. Human Molecular Genetics 1995; 4:1657-63.
  • Liu AW, Delgado-Escueta AV, Serratosa JM, Alonso ME, Medina NT, Gee MN, Cordova S, Zhao HZ, Spellman JM, Ramos-Peek JR, Rubio Donnadieu F, Sparkes RS. Juvenile myoclonic epilepsy locus in 6p21.2-p11: linkage to convulsions and electroencephalography trait. Am J Hum Genet 1995; 57:368-81.
  • Unidad de Epilepsia Certificada por la Academia Europea de Epilepsia (EUREPA)
  • Trainer en Epileptología de la Academia Europea de Epilepsia (EUREPA)