Regenerative Medicine and Tissue Bioengineering Associated Group

Medicina regenerativa - foto grupo2025 DATA

Gender perspective

Medicina regenerativa-01

Summary of activities

Among our main research activities are:

• Clinical, pathophysiological, cellular and genetic characterisation of genodermatoses and other skin disorders.
• Tissue bioengineering approaches based on Adult Stem Cells, including Mesenchymal Stem Cells and Epithelial Stem Cells, for skin regeneration.
• Development of cellular and gene therapy strategies, including gene-editing approaches, for the treatment of genodermatoses.
• Development of cellular and gene therapy strategies, including gene-editing approaches, for the treatment of genodermatoses.

Contributions to society

Over the last four years, the group has disseminated its scientific activity through numerous publications, invited lectures and science outreach events. The group participates in multiple research projects funded through competitive calls, R&D contracts with the pharmaceutical industry, collaborations with patient associations and partnerships with private institutions. During this period, three new patents have been obtained, and the group has participated in two clinical trials in the field of regenerative skin medicine. Particular recognition should be given to the involvement of Group members as advisors to DEBRA Spain (Epidermolysis Bullosa) and the Spanish Association of Patients with Ichthyosis, as well as their participation in EB-Clinet, the international network of Epidermolysis Bullosa centres, the Medical and Scientific Advisory Panel (MSAP) of DEBRA International, and the Executive Committee of the European Society for Dermatological Research (ESDR).

Collaborations

The Group maintains close collaborations through joint research projects and scientific publications with:

• MEDICAL CENTER– UNIVERSITY OF FREIBURG University Hospital of Freiburg (Freiburg, Germany).
• Leitung Molekulare Dermatologie Leitung Genodermatosen-Sprechstunde UNIVERSITÄTSKLINIKUM FREIBURG. (Germany).
• St John’s Institute of Dermatology, King’s College London (London, UK).
• IHU IMAGINE – Institut des maladies génétiques. Paris (France).
• Laboratorio di Biologia Molecolare e Cellulare Istituto Dermopatico dell'Immacolata – IRCCS. Rome (Italy).

PhD Theses

Medicina regenerativa-02

List of publications

Absolute Quantification and Spatial Mapping of Hyaluronic Acid in Histological Tissue Sections.

Quílez C, González-Rico J, López-Donaire ML, Gago-López N, Muñoz-Barrutia A, Velasco D.

ACS Meas Sci Au. 2026 Feb 18.6(1):21-27.

PMID: 41727366

FI: 9

http://dx.doi.org/10.1021/acsmeasuresciau.5c00138

Isolation, characterization, and vascular potential of porcine cells in a three-dimensional decellularized liver matrix model.

Morini S, Melitón Barbancho S, Blanes Rodríguez Á, Pla-Palacín I, Sainz-Arnal P, Sánchez-Romero N, Falceto MV, Mitjana O, Romero A, Del Rio-Nechaevsky M, Bengochea Martinez ML, Olmedo Arbizu E, Lorente S, Lanas A, Fernandes-Platzgummer A, Baptista PM.

Front Bioeng Biotechnol. 2025.13:1625999.

PMID: 40831624

FI: 4,8

http://dx.doi.org/10.3389/fbioe.2025.1625999

Mathematical models and computational approaches in CAR-T therapeutics.

Putignano G, Ruipérez-Campillo S, Yuan Z, Millet J, Guerrero-Aspizua S.

Front Immunol. 2025.16:1581210.

PMID: 40821789

FI: 5,9

http://dx.doi.org/10.3389/fimmu.2025.1581210

Base edited skin equivalents with clinical potential for ex vivo correction of recessive dystrophic epidermolysis bullosa.

Bassons-Bascuñana A, Duarte B, Méndez-Jiménez E, Ugalde L, Sanabria-Betrián P, Aussel C, Peña-Gutiérrez I, Olalla-Sastre B, Ammann S, Cathomen T, Del Rio M, Río P, Larcher F, López-Manzaneda S.

Mol Ther. 2025 Nov 17.

PMID: 41254941

FI: 12

http://dx.doi.org/10.1016/j.ymthe.2025.11.023

Optimizing a feasible protocol for acellular nerve allografts: An experimental study.

Camporro Fernández D, de Juan Marín M, Pevida M, Llames S, Argüelles Luís J, Meana Á.

Cell Tissue Bank. 2025 Oct 30.26(4):49.

PMID: 41165870

FI: 2

http://dx.doi.org/10.1007/s10561-025-10189-w

Sephardic origins revealed for rare skin disorder, recessive dystrophic epidermolysis bullosa, in individuals carrying the unique c.6527insC mutation.

Warshauer EM, Maier PA, Runfeldt G, Fuentes I, Escamez MJ, Valinotto L, Natale M, Manzur G, Illera N, Garcia M, Del Rio M, Mencia A, Holguin A, Larcher F, Hellenthal G, Brown AR, Consuegra L, Rivera C, Nogueiro I, Tang J, Oro A, Marinkovich P, Palisson F, Titeux M, Hovnanian AA, Sprecher E, Skorecki K, Norris D, Bruckner A, Kogut I, Bilousova G, Roop D.

J Med Genet. 2025 Sep 24.

PMID: 40992924

FI: 3,7

http://dx.doi.org/10.1136/jmg-2025-110967

Targeting olfactory receptor OR2AT4: An innovative aptamer-based treatment for hair growth promotion.

Mataix M, Illera N, Hidalgo I, Arriba MDC, Martín E, Fernández G, González C, Larcher F, González VM, Rio MD, Jiménez F, Carretero M.

Mol Ther Nucleic Acids. 2025 Sep 09.36(3):102608.

PMID: 40686857

FI: 6,1

http://dx.doi.org/10.1016/j.omtn.2025.102608

The Importance of Shared Patient Voices in Advancing Science for Genodermatoses on a Global Scale.

van Veen FCAP, Sprecher E, Schwartz J, Baker T, O'Toole EA, Veldman K, Aldwin-Easton M, Gliksohn A, Dlova N, Larcher F, Tarrats N, Rajan N, Gostyński AH.

J Invest Dermatol. 2025 Sep;145(9):2127-2130.

PMID: 40600863

FI: 5,7

http://dx.doi.org/10.1016/j.jid.2025.05.027

Injectable hyaluronic acid hydrogels via Michael addition as dermal fillers for skin regeneration applications.

Pérez LA, Alonso JM, Pérez-González R, Velasco D, Suárez-Cabrera L, de Aranda-Izuzquiza G, Sáez-Martínez V, Hernández R.

Biomater Adv. 2025 Jun 02.177:214364.

PMID: 40516273

FI: 6

http://dx.doi.org/10.1016/j.bioadv.2025.214364

Safe and Efficacious Permanent Removal of Large COL7A1 Exons for Gene Reframing as a Reliable Therapeutic Strategy for Recessive Dystrophic Epidermolysis Bullosa.

López-Manzaneda S, Mencía Á, Bonafont J, Bassons-Bascuñana A, García M, Nyström A, Duarte B, Llames S, Murillas R, Modamio-Hoybjor S, Morín M, Soletto L, Escamez MJ, Moreno-Pelayo MA, Rio MD, Larcher F.

Hum Gene Ther. 2025 May 28.

PMID: 40432605

FI: 4

http://dx.doi.org/10.1089/hum.2024.238

Interplay between iron metabolism, inflammation, and EPO-ERFE-hepcidin axis in RDEB-associated chronic anemia.

Quintana-Castanedo L, Maseda R, Pérez-Conde I, Butta N, Monzón-Manzano E, Acuña-Butta P, Crespo MG, Buño-Soto A, Jiménez E, Valencia J, Arriba MC, Zuluaga P, de Lucas R, Del Río M, Vicente Á, Escámez MJ, Sacedón R.

Blood Adv. 2025 May 13.9(9):2321-2335.

PMID: 40036737

FI: 7,1

http://dx.doi.org/10.1182/bloodadvances.2024015271