CRM (Cardiovascular, Renal and Metabolic Diseases)

Area coordinators:

• Alberto Ortiz Arduán
  AOrtiz@fjd.es
  Consult CV
• Carmen Gómez Guerrero
  Cgomez@fjd.es
  Consult CV
• Carmen Garcés Segura
  CGarces@fjd.es
  Consult CV

Foto1

Its objectives include:

• To advance the understanding of the mechanisms of injury and repair in renal, urological, cardiovascular and metabolic diseases, including diabetes, across the lifespan, starting from childhood. Within this common framework, each group and subgroup focuses on specific aspects of these disorders, sharing expertise and technologies to accelerate scientific discovery and facilitate the translation of research findings into clinical practice.
• To investigate the cellular and molecular mechanisms involved in the pathogenesis of selected diseases, including fibrosis, immune-inflammatory responses, apoptosis, intracellular signalling pathways, cytokines and the renin-angiotensin system, among others. These studies encompass conditions such as atherothrombosis, myocardial ischaemia-reperfusion injury, cardiomyopathies, diabetic kidney disease, hypertension, glomerular diseases, acute kidney injury, nephrotoxicity, obesity and diabetes
• To apply advanced platforms and imaging technologies, including proteomics, genomics, metabolomics, cardiac magnetic resonance imaging and molecular imaging, to identify novel molecules with diagnostic and therapeutic potential in the above-mentioned diseases.
• To discover and undertake preclinical development of novel therapeutic approaches for the prevention and treatment of cardiovascular, renal and metabolic diseases, with the goal of their translation into clinical practice

Excessive glycosylation drives thoracic aortic aneurysm formation through integrated stress response.

Rochano-Ortiz A, San Sebastián-Jaraba I, Zamora C, Simó C, García-Cañas V, Martínez-Albaladejo S, Fernández-Gómez MJ, Marcos-Ríos D, Martínez-Núñez P, Martín-Lorenzo M, Velho TR, Ruíz-Rodríguez MJ, Leal-Zafra A, Gabandé-Rodríguez E, Martínez-Martínez S, Guala A, Lorenzo Ó, Blanco-Colio LM, Martín-Ventura JL, Álvarez-Llamas G, Aldamiz-Echevarría G, Teixidó-Tura G, Forteza A, Nistal JF, Redondo JM, Méndez-Barbero N, Mittelbrunn M, Oller J.

Eur Heart J. 2025 Dec 01.46(45):4988-5005.

PMID: 40720766

IF: 35,7

http://dx.doi.org/10.1093/eurheartj/ehaf556

Beta-Blockers after Myocardial Infarction without Reduced Ejection Fraction.

Ibanez B, Latini R, Rossello X, Dominguez-Rodriguez A, Fernández-Vazquez F, Pelizzoni V, Sánchez PL, Anguita M, Barrabés JA, Raposeiras-Roubín S, Pocock S, Escalera N, Staszewsky L, Pérez-García CN, Díez-Villanueva P, Pérez-Rivera JA, Prada-Delgado O, Owen R, Pizarro G, Caldes O, Gómez-Talavera S, Tuñón J, Bianco M, Zarauza J, Vetrano A, Campos A, Martínez-Huertas S, Bueno H, Puentes M, Grigis G, Bonilla-Palomas JL, Marco E, González-Juanatey JR, Bangueses R, González-Juanatey C, García-Álvarez A, Ruiz-García J, Carrasquer A, García-Rubira JC, Pascual-Figal D, Tomás-Querol C, San Román JA, Baratta P, Agüero J, Martín-Reyes R, Colivicchi F, Ortas-Nadal R, Bazal P, Cordero A, Fernández-Ortiz A, Basso P, González E, Poletti F, Bugani G, Debiasio M, Cosmi D, Navazio A, Bermejo J, Tortorella G, Marini M, Botas J, de la Torre-Hernández JM, Ottani F, Fuster V, REBOOT-CNIC Investigators.

N Engl J Med. 2025 Nov 13.393(19):1889-1900.

PMID: 40888702

IF: 78,5

http://dx.doi.org/10.1056/NEJMoa2504735

Sleep-Wake Cycle and Circadian Misalignment in People With Autism Across the Lifespan With an Emphasis on Living Conditions.

Martínez-Cayuelas E, García-Muñoz AM, de Ocaña-Moreno MLS, Richdale AL, Gisbert-Gustemps L, Lugo-Marín J, Rodríguez-Morillas B, Peiró-Peiró AM, Victoria-Montesinos D, López-Anguas C, Meseguer-Illán MD, Ballester-Navarro P.

Autism Res. 2025 Jun 02.

PMID: 40452585

IF: 5,6

http://dx.doi.org/10.1002/aur.70058

Global, regional, and national prevalence of child and adolescent overweight and obesity, 1990-2021, with forecasts to 2050: a forecasting study for the Global Burden of Disease Study 2021.

GBD 2021 Adolescent BMI Collaborators (Ortiz A).

Lancet. 2025 Mar 08.405(10481):785-812.

PMID: 40049185

IF: 88,5

http://dx.doi.org/10.1016/S0140-6736(25)00397-6

Evaluation and Analysis of Costs Associated with Prophylaxis of Recurrent Urinary Tract Infections (RUTIs) in Women.

Hernández-Sánchez JE, Szczesnieski JJ, Padilla-Fernández BY, González-Enguita C, Flores-Fraile J, Lorenzo-Gómez MF.

Microorganisms. 2025 Feb 11.13(2).

PMID: 40005759

IF: 4,2

http://dx.doi.org/10.3390/microorganisms13020393

Gender Perspective in the CRM Area (Cardiovascular, Renal and Metabolic Diseases)

The CRM Area is composed of a team of professionals committed to respect, diversity and equality among its members. The Area seeks to promote the professional development of all staff, ensuring equal opportunities and preventing discrimination on the grounds of gender or age.

Género

Future Challenges for the CRM Area (Cardiovascular, Renal and Metabolic Diseases)

• To improve outcomes in kidney diseases through the development of novel diagnostic and risk stratification tools, as well as new therapeutic strategies.
• To improve outcomes in kidney diseases through the development of novel diagnostic and risk stratification tools, as well as new therapeutic strategies.
• To improve outcomes in cardiovascular diseases through the development of novel diagnostic and risk stratification tools, as well as new therapeutic strategies.
• To implement innovative therapeutic strategies and Health Outcomes Assessment approaches in Urological Diseases.

Research Groups

• Cardiology
• Nephrology and Hypertension, Vascular Disease and Diabetes
• Lipid Disorders: Clinical and Experimental (adults and children)

• Cardiac and Vascular Surgery Associated Group
• Urology Associated Group