Terapias Avanzadas

Responsable

• Juan Bueren (CIEMAT)
  juan.bueren@ciemat.es
  Consulte su CV (158.3 KB) (4 páginas)

IPs

• Marina Inmaculada Garín Ferreira
• José Carlos Segovia Sanz
• Rosa María Yáñez González
• Paula Río Galdo

Investigación

• Básica
• Clínica

Producción científica

Resumen 2020

Publicaciones 2020

Involvement of Mesenchymal Stem Cells in Oral Mucosal Bacterial Immunotherapy.

Vázquez A, Fernández-Sevilla LM, Jiménez E, Pérez-Cabrera D, Yañez R, Subiza JL, Varas A, Valencia J, Vicente A.

Frontiers in immunology. 2020 Nov 19;11:567391.

PMID: 33329530

FI: 5,085

In vivo CRISPR/Cas9 targeting of fusion oncogenes for selective elimination of cancer cells.

Martinez-Lage M, Torres-Ruiz R, Puig-Serra P, Moreno-Gaona P, Martin MC, Moya FJ, Quintana-Bustamante O, Garcia-Silva S, Carcaboso AM, Petazzi P, Bueno C, Mora J, Peinado H, Segovia JC, Menendez P, Rodriguez-Perales S.

Nature communications. 2020 Oct 8;11(1):5060.

PMID: 33033246

FI: 12,121

Cell therapy with mesenchymal stem cells induces an innate immune memory response that attenuates experimental colitis in the long-term.

Lopez-Santalla M, Hervas-Salcedo R, Fernandez-Garcia M, Bueren JA, Garin MI.

Journal of Crohn's &colitis. 2020 Oct 5;14(10):1424-1435.

PMID: 32318720

FI: 8,658

Mesenchymal Stem/Stromal Cells for Rheumatoid Arthritis Treatment: An Update on Clinical Applications.

Lopez-Santalla M, Fernandez-Perez R, Garin MI.

Cells. 2020 Aug 7;9(8):1852.

PMID: 32784608

FI: 4,366

Human Pluripotent Stem Cell-Derived Neurons Are Functionally Mature In Vitro and Integrate into the Mouse Striatum Following Transplantation.

Comella-Bolla A, Orlandi JG, Miguez A, Straccia M, García-Bravo M, Bombau G, Galofré M, Sanders P, Carrere J, Segovia JC, Blasi J, Allen ND, Alberch J, Soriano J, Canals JM.

Molecular neurobiology. Epub 2020 Apr 30. 2020 Jun;57(6):2766-2798.

PMID: 32356172

FI: 4,5

Natural estrogens enhance the engraftment of human hematopoietic stem and progenitor cells in immunodeficient mice.

Fañanas-Baquero S, Orman I, Becerra Aparicio F, Bermudez de Miguel S, Garcia Merino J, Yañez R, Fernandez Sainz Y, Sánchez R, Dessy-Rodríguez M, Alberquilla O, Alfaro D, Zapata A, Bueren JA, Segovia JC, Quintana-Bustamante O.

Haematologica. 2020 Apr 30.

PMID: 32354868

FI: 7,116

The downregulated membrane expression of CD18 in CD34+ cells defines a primitive population of human hematopoietic stem cells.

Mesa-Núñez C, Leon-Rico D, Aldea M, Damián C, Sanchez-Baltasar R, Sanchez R, Alberquilla O, Segovia JC, Bueren JA, Almarza E.

Stem cell research &therapy. 2020 Apr 28;11(1):164.

PMID: 32345365

FI: 5,116

TALEN mediated gene editing in a mouse model of Fanconi anemia.

Pino-Barrio MJ, Giménez Y, Villanueva M, Hildenbeutel M, Sánchez-Dominguez R, Rodríguez-Perales S, Pujol R, Surrallés J, Río P, Cathomen T, Mussolino C, Bueren JA, Navarro S.

Scientific reports. 2020 Apr 24;10(1):6997.

PMID: 32332829

FI: 3,998

Midkine signaling maintains the self-renewal and tumorigenic capacity of glioma initiating cells.

López-Valero I, Dávila D, González-Martínez J, Salvador-Tormo N, Lorente M, Saiz-Ladera C, Torres S, Gabicagogeascoa E, Hernández-Tiedra S, García-Taboada E, Mendiburu-Eliçabe M, Rodríguez-Fornés F, Sánchez-Domínguez R, Segovia JC, Sánchez-Gómez P, Matheu A, Sepúlveda JM, Velasco G.

Theranostics. 2020 Apr 6;10(11):5120-5136.

PMID: 32308772

FI: 8,579

Targeted gene therapy into a safe harbor site in human hematopoietic progenitor cells.

Rodriguez-Fornes F, Quintana-Bustamante O, Lozano ML, Segovia JC, Bueren JA, Guenechea G.

Gene therapy. Epub 2020 Mar 26. 2020 Sep;27(9):435-450.

PMID: 32218505

FI: 4,128

Mosaicism in Fanconi anemia: concise review and evaluation of published cases with focus on clinical course of blood count normalization.

Nicoletti E, Rao G, Bueren JA, Río P, Navarro S, Surrallés J, Choi G, Schwartz JD.

Annals of hematology. Epub 2020 Feb 17. 2020 May;99(5):913-924.

PMID: 32065290

FI: 2,904

Gefitinib and Afatinib Show Potential Efficacy for Fanconi Anemia-Related Head and Neck Cancer.

Montanuy H, Martínez-Barriocanal Á, Antonio Casado J, Rovirosa L, Ramírez MJ, Nieto R, Carrascoso-Rubio C, Riera P, González A, Lerma E, Lasa A, Carreras-Puigvert J, Helleday T, Bueren JA, Arango D, Minguillón J, Surrallés J.

Clinical cancer research. Epub 2020 Jan 31. 2020 Jun 15;26(12):3044-3057.

PMID: 32005748

FI: 10,107

IKKβ overexpression together with a lack of tumour suppressor genes causes ameloblastic odontomas in mice.

Page A, Bravo A, Suarez-Cabrera C, Sanchez-Baltasar R, Oteo M, Morcillo MA, Casanova ML, Segovia JC, Navarro M, Ramirez A.

International journal of oral science. 2020 Jan 2;12(1):1.

PMID: 31900382

FI: 3,047

Optimised molecular genetic diagnostics of Fanconi anaemia by whole exome sequencing and functional studies.

Bogliolo M, Pujol R, Aza-Carmona M, Muñoz-Subirana N, Rodriguez-Santiago B, Casado JA, Rio P, Bauser C, Reina-Castillón J, Lopez-Sanchez M, Gonzalez-Quereda L, Gallano P, Catalá A, Ruiz-Llobet A, Badell I, Diaz-Heredia C, Hladun R, Senent L, Argiles B, Bergua Burgues JM, Bañez F, Arrizabalaga B, López Almaraz R, Lopez M, Figuera Á, Molinés A, Pérez de Soto I, Hernando I, Muñoz JA, Del Rosario Marin M, Balmaña J, Stjepanovic N, Carrasco E, Cuesta I, Cosuelo JM, Regueiro A, Moraleda Jimenez J, Galera-Miñarro AM, Rosiñol L, Carrió A, Beléndez-Bieler C, Escudero Soto A, Cela E, de la Mata G, Fernández-Delgado R, Garcia-Pardos MC, Sáez-Villaverde R, Barragaño M, Portugal R, Lendinez F, Hernadez I, Vagace JM, Tapia M, Nieto J, Garcia M, Gonzalez M, Vicho C, Galvez E, Valiente A, Antelo ML, Ancliff P, Garcia F, Dopazo J, Sevilla J, Paprotka T, Pérez-Jurado LA, Bueren J, Surralles J.

Journal of medical genetics. Epub 2019 Oct 5. 2020 Apr;57(4):258-268.

PMID: 31586946

FI: 4,943

Theranostic Viral Nanoparticles for Autoimmune Diseases.

Yuste-Calvo C, López-Santalla M, Garín M.I and Ponz F.

Journal of Immunobiology 2020. 5: 149

PMID:

FI: 0

Proyectos, Contratos y EOs vigentes 2020

Fuentes de financiación públicas de proyectos que se están desarrollando en el IIS-FJD:

ORGANISMOS PÚBLICOS DE FINANCIACIÓN

Patentes

1. Título: "Improvements for performing and facilitating the recovery after hematopoietic stem cell transplantation"

Nº solicitud: EP18382779.9 y PCT/EP2019/079945

Entidades titulares: CIEMAT (80%); CIBER (12%); FIIS-FJD (8%)

Inventores: Oscar Quintana; José Antonio Bueren; José Carlos Segovia.

2. Título: "Pyruvate kinase deficiency (PKD) gene editing treatment method"

Nº solicitud: EP20382568.2

Entidades titulares: CIEMAT (63%), CIBER (12,9 %), IISFJD (14,1 %) Y UNIV. STANFORD (10%)

Inventores: Jose Carlos Segovia, Oscar Quintana, Sara Fañanas, Matthew Porteus.