A continuación se detallan las publicaciones más relevantes de 2019:

  • Área de Cáncer.

The Role of MicroRNAs in Hepatoblastoma Tumors.

Cristóbal I, Sanz-Álvarez M, Luque M, Caramés C, Rojo F, García-Foncillas J.

Cancers 2019 Mar 22;11(3). pii: E409.

PMID: 30909459

FI: 6,162


Defects in memory B-cell and plasma cell subsets expressing different immunoglobulin-subclasses in patients with CVID and immunoglobulin subclass deficiencies.

Blanco E, Pérez-Andrés M, Arriba-Méndez S, Serrano C, Criado I, Del Pino-Molina L, Silva S, Madruga I, Bakardjieva M, Martins C, Serra-Caetano A, Romero A, Contreras-Sanfeliciano T, Bonroy C, Sala F, Martín A, Bastida JM, Lorente F, Prieto C, Dávila I, Marcos M, Kalina T, Vlkova M, Chovancova Z, Cordeiro AI, Philippé J, Haerynck F, López-Granados E, Sousa AE, van der Burg M, van Dongen JJM, Orfao A, EuroFlow PID group..

The Journal of allergy and clinical immunology Epub 2019 Feb 28. 2019 Sep;144(3):809-824.

PMID: 30826363

FI: 14,11


Tumor Associated Fibroblasts Promote HER2-Targeted Therapy Resistance through FGFR2 Activation.

Fernandez-Nogueira P, Mancino M, Fuster G, Lopez-Plana A, Jauregui P, Almendro V, Enreig E, Menéndez S, Rojo F, Noguera-Castells A, Bill A, Gaither LA, Serrano L, Recalde-Percaz L, Moragas N, Alonso R, Ametller E, Rovira A, Lluch A, Albanell J, Gascon P, Bragado P.

Clinical cancer research 2019 Nov 7.

PMID: 31699826

FI: 8,911


CD30-positive primary cutaneous lymphoproliferative disorders: molecular alterations and targeted therapies.

Prieto-Torres L, Rodriguez-Pinilla SM, Onaindia A, Ara M, Requena L, Piris MÁ.

Haematologica Epub 2019 Jan 10. 2019 Feb;104(2):226-235.

PMID: 30630983

FI: 7,57


Periprocedural safety and technical outcomes of the new Silk Vista Baby flow diverter for the treatment of intracranial aneurysms: results from a multicenter experience.

Martínez-Galdámez M, Biondi A, Kalousek V, Pereira VM, Ianucci G, Gentric JC, Mosimann PJ, Brisbois D, Schob S, Quäschling U, Kaesmacher J, Ognard J, Escartín J, Tsang COA, ?ulo B, Chabert E, Turjman F, Barbier C, Mihalea C, Spelle L, Chapot R.

Journal of neurointerventional surgery Epub 2019 Mar 9. 2019 Jul;11(7):723-727.

PMID: 30852525

FI: 3,925


  • Área de Enfermedades Infecciosas, Inflamatorias y Crónicas.

Long-term clinical effectiveness of continuous positive airway pressure therapy versus non-invasive ventilation therapy in patients with obesity hypoventilation syndrome: a multicentre, open-label, randomised controlled trial.

Masa JF, Mokhlesi B, Benítez I, Gomez de Terreros FJ, Sánchez-Quiroga MÁ, Romero A, Caballero-Eraso C, Terán-Santos J, Alonso-Álvarez ML, Troncoso MF, González M, López-Martín S, Marin JM, Martí S, Díaz-Cambriles T, Chiner E, Egea C, Barca J, Vázquez-Polo FJ, Negrín MA, Martel-Escobar M, Barbe F, Corral J, Spanish Sleep Network..

Lancet Epub 2019 Mar 29. 2019 Apr 27;393(10182):1721-1732.

PMID: 30935737

FI: 59,102


The TNF-like weak inducer of the apoptosis/fibroblast growth factor-inducible molecule 14 axis mediates histamine and platelet-activating factor-induced subcutaneous vascular leakage and anaphylactic shock.

Mendez-Barbero N, Yuste-Montalvo A, Nuñez-Borque E, Jensen BM, Gutiérrez-Muñoz C, Tome-Amat J, Garrido-Arandia M, Díaz-Perales A, Ballesteros-Martinez C, Laguna JJ, Beitia JM, Poulsen LK, Cuesta-Herranz J, Blanco-Colio LM, Esteban V.

The Journal of allergy and clinical immunology. 2019 Oct 31. pii: S0091-6749(19)31255-2.

PMID: 31679818

FI: 14,11


Recessive mutations in muscle-specific isoforms of FXR1 cause congenital multi-minicore myopathy.

Estañ MC, Fernández-Núñez E, Zaki MS, Esteban MI, Donkervoort S, Hawkins C, Caparros-Martin JA, Saade D, Hu Y, Bolduc V, Chao KR, Nevado J, Lamuedra A, Largo R, Herrero-Beaumont G, Regadera J, Hernandez-Chico C, Tizzano EF, Martinez-Glez V, Carvajal JJ, Zong R, Nelson DL, Otaify GA, Temtamy S, Aglan M, Issa M, Bönnemann CG, Lapunzina P, Yoon G, Ruiz-Perez VL.

Nature communications 2019 Feb 15;10(1):797.

PMID: 30770808

FI: 11,878


Surveillance of adverse events in the treatment of drug-resistant tuberculosis: first global report.

Borisov S, Danila E, Maryandyshev A, Dalcolmo M, Miliauskas S, Kuksa L, Manga S, Skrahina A, Diktanas S, Codecasa LR, Aleksa A, Bruchfeld J, Koleva A, Piubello A, Udwadia ZF, Akkerman OW, Belilovski E, Bernal E, Boeree MJ, Loidi JC, Cai Q, Cebrian Gallardo JJ, Dara M, Davidaviien E, Forsman LD, De Los Rios Jefe J, Denholm J, Drakšien? J, Duarte R, Elamin SE, Salinas NE, Ferrarese M, Filippov A, Garcia A, García-García JM, Gaudiesiute I, Gavazova B, Gayoso R, Rosso RG, Gruslys V, Gualano G, Hoefsloot W, Jonsson J, Khimova E, Kunst H, Laniado-Laborín R, Li Y, Magis-Escurra C, Manfrin V, Marchese V, Robles EM, Matteelli A, Mazza-Stalder J, Moschos C, Munoz-Torrico M, Hamdan HM, Nak?erien? B, Nicod L, Marcos MN, Palmero DJ, Palmieri F, Papavasileiou A, Payen MC, Pontarelli A, Quirós S, Rendon A, Saderi L, Šmite A, Solovic I, Souleymane MB, Tadolini M, van den Boom M, Vescovo M, Viggiani P, Yedilbayev A, Zablockis R, Zhurkin D, Zignol M, Visca D, Spanevello A, Caminero JA, Alffenaar JW, Tiberi S, Centis R, D'Ambrosio L, Pontali E, Sotgiu G, Migliori GB.

European respiratory journal 2019 Oct 10. pii: 1901522.

PMID: 31601711

FI: 11,807


Orthopedic Implant-Associated Infection by Multidrug Resistant Enterobacteriaceae.

Pfang BG, García-Cañete J, García-Lasheras J, Blanco A, Auñón Á, Parron-Cambero R, Macías-Valcayo A, Esteban J.

Journal of clinical medicine 2019 Feb 8;8(2). pii: E220.

PMID: 30744054

FI: 5,688


  • Área de Neurociencias.

Elevated levels of Secreted-Frizzled-Related-Protein 1 contribute to Alzheimer's disease pathogenesis.

Esteve P, Rueda-Carrasco J, Inés Mateo M, Martin-Bermejo MJ, Draffin J, Pereyra G, Sandonís Á, Crespo I, Moreno I, Aso E, Garcia-Esparcia P, Gomez-Tortosa E, Rábano A, Fortea J, Alcolea D, Lleo A, Heneka MT, Valpuesta JM, Esteban JA, Ferrer I, Domínguez M, Bovolenta P.

Nature neuroscience Epub 2019 Jul 15. 2019 Aug;22(8):1258-1268

PMID: 31308530

FI: 21,126


The Genetic Architecture of Parkinson Disease in Spain: Characterizing Population-Specific Risk, Differential Haplotype Structures, and Providing Etiologic Insight.

Bandres-Ciga S, Ahmed S, Sabir MS, Blauwendraat C, Adarmes-Gómez AD, Bernal-Bernal I, Bonilla-Toribio M, Buiza-Rueda D, Carrillo F, Carrión-Claro M, Gómez-Garre P, Jesús S, Labrador-Espinosa MA, Macias D, Méndez-Del-Barrio C, Periñán-Tocino T, Tejera-Parrado C, Vargas-González L, Diez-Fairen M, Alvarez I, Tartari JP, Buongiorno M, Aguilar M, Gorostidi A, Bergareche JA, Mondragon E, Vinagre-Aragon A, Croitoru I, Ruiz-Martínez J, Dols-Icardo O, Kulisevsky J, Marín-Lahoz J, Pagonabarraga J, Pascual-Sedano B, Ezquerra M, Cámara A, Compta Y, Fernández M, Fernández-Santiago R, Muñoz E, Tolosa E, Valldeoriola F, Gonzalez-Aramburu I, Sanchez Rodriguez A, Sierra M, Menéndez-González M, Blazquez M, Garcia C, Suarez-San Martin E, García-Ruiz P, Martínez-Castrillo JC, Vela-Desojo L, Ruz C, Barrero FJ, Escamilla-Sevilla F, Mínguez-Castellanos A, Cerdan D, Tabernero C, Gomez Heredia MJ, Perez Errazquin F, Romero-Acebal M, Feliz C, Lopez-Sendon JL, Mata M, Martínez Torres I, Kim JJ, Dalgard CL, American Genome Center., Brooks J, Saez-Atienzar S, Gibbs JR, Jorda R, Botia JA, Bonet-Ponce L, Morrison KE, Clarke C, Tan M, Morris H, Edsall C, Hernandez D, Simon-Sanchez J, Nalls MA, Scholz SW, Jimenez-Escrig A, Duarte J, Vives F, Duran R, Hoenicka J, Alvarez V, Infante J, Marti MJ, Clarimón J, López de Munain A, Pastor P, Mir P, Singleton A, International Parkinson Disease Genomics Consortium.

MOVEMENT DISORDERS 2019 Oct 29.

PMID: 31660654

FI: 8,222


Creativity related to dopaminergic treatment: A multicenter study.

Garcia-Ruiz PJ, Martinez Castrillo JC, Desojo LV.

Parkinsonism &related disorders Epub 2019 Feb 22. 2019 Jun;63:169-173.

PMID: 30824283

FI: 4,36


Mining social networks to improve suicide prevention: A scoping review.

Lopez-Castroman J, Moulahi B, Azé J, Bringay S, Deninotti J, Guillaume S, Baca-Garcia E.

Journal of neuroscience research 2019 Feb 27.

PMID: 30809836

FI: 4,139


Beyond Statistical Significance: An Underrated Suicide Prevention Intervention.

Martínez-Alés G, Keyes KM, Baca-García E.

Journal of clinical psychiatry 2019 Jun 18;80(4). pii: 19lr12814.

PMID: 31237993

FI: 4,023



  • Área de Enfermedades Renales, Metabólicas y Cardiovasculares.

Working towards novel albuminuria endpoints in chronic kidney disease.

Fernandez-Fernandez B, Sanchez-Niño MD, Ortiz A.

The lancet. Diabetes &endocrinology Epub 2019 Jan 8. 2019 Feb;7(2):80-82

PMID: 30635227

FI: 24,54


Darolutamide in Nonmetastatic, Castration-Resistant Prostate Cancer.

Fizazi K, Shore N, Tammela TL, Ulys A, Vjaters E, M, Alekseev B, Kuss I, Kappeler C, Snapir A, Sarapohja Polyakov S, Jievaltas M, LuzT, Smith MR; ARAMIS Investigators. (González-Enguita C).

N Engl J Med Epub 2019 Feb 14. 2019 Mar 28;380(13):1235-1246.

PMID: 30763142

FI: 70,67


And fibrinolysis became pharmacoinvasive.

Ibanez B.

European heart journal 2019 Oct 12. pii: ehz716.

PMID: 31605481

FI: 24,889


Mapping 123 million neonatal, infant and child deaths between 2000 and 2017.

Burstein R, Henry NJ, Collison ML, et al (Alberto Ortiz).

Nature Epub 2019 Oct 16. 2019 Oct;574(7778):353-358.

PMID: 31619795

FI: 43,07


Sex-specific association of plasma nesfatin-1 concentrations with obesity in children.

de Dios O, Herrero L, Gavela-Pérez T, Soriano-Guillén L, Garcés C.

Pediatric obesity Epub 2019 Sep 10. 2019 Dec;14(12):e12567.

PMID: 31507101

FI: 3,713



  • Área de Genética y Genómica.

NHEJ-Mediated Repair of CRISPR-Cas9-Induced DNA Breaks Efficiently Corrects Mutations in HSPCs from Patients with Fanconi Anemia.

Román-Rodríguez FJ, Ugalde L, Álvarez L, Díez B, Ramírez MJ, Risueño C, Cortón M, Bogliolo M, Bernal S, March F, Ayuso C, Hanenberg H, Sevilla J, Rodríguez-Perales S, Torres-Ruiz R, Surrallés J, Bueren JA, Río P.

Cell Stem Cell Epub 2019 Sep 19. 2019 Nov 7;25(5):607-621.e7.

PMID: 31543367

FI: 21,464


Novel locus for atopic dermatitis in African Americans and replication in European Americans.

Almoguera B, Vazquez L, Mentch F, March ME, Connolly JJ, Peissig PL, Linneman JG, Plaza-Serón MDC, Pino-Yanes M, Burchard EG, Brilliant M, Sleiman P, Hakonarson H.

The Journal of allergy and clinical immunology Epub 2018 Nov 9. 2019 Mar;143(3):1229-1231.

PMID: 30414857

FI: 14,11


Genomic Landscape of Sporadic Retinitis Pigmentosa: Findings from 877 Spanish Cases.

Martin-Merida I, Avila-Fernandez A, Del Pozo-Valero M, Blanco-Kelly F, Zurita O, Perez-Carro R, Aguilera-Garcia D, Riveiro-Alvarez R, Arteche A, Trujillo-Tiebas MJ, Tahsin-Swafiri S, Rodriguez-Pinilla E, Lorda-Sanchez I, Garcia-Sandoval B, Corton M, Ayuso C.

Ophthalmology Epub 2019 Mar 20. 2019 Aug;126(8):1181-1188.

PMID: 30902645

FI: 7,732


A major role of TWEAK/Fn14 axis as a therapeutic target for post-angioplasty restenosis.

Méndez-Barbero N, Gutierrez-Muñoz C, Madrigal-Matute J, Mínguez P, Egido J, Michel JB, Martín-Ventura JL, Esteban V, Blanco-Colio LM.

EBioMedicine Epub 2019 Aug 5. 2019 Aug;46:274-289.

PMID: 31395500

FI: 6,68


Downregulation of specific FBXW7 isoforms with differential effects in T-cell lymphoblastic lymphoma.

Vázquez-Domínguez I, González-Sánchez L, López-Nieva P, Fernández-Navarro P, Villa-Morales M, Cobos-Fernández MÁ, Sastre I, F Fraga M, F Fernández A, Malumbres M, Salazar-Roa M, Graña-Castro O, Santos J, Llamas P, López-Lorenzo JL, Fernández-Piqueras J.

Oncogene Epub 2019 Feb 11. 2019 Jun;38(23):4620-4636.

PMID: 30742097

FI: 6,634


  • Área de Tecnología e Innovación Sanitaria.

An Umbilical Nodule.

Barambio J, Brandariz L.

New England journal of medicine 2019 Mar 14;380(11):1061.

PMID: 30865800

FI: 70,67


Successful engraftment of gene-corrected hematopoietic stem cells in non-conditioned patients with Fanconi anemia.

Río P, Navarro S, Wang W, Sánchez-Domínguez R, Pujol RM, Segovia JC, Bogliolo M, Merino E, Wu N, Salgado R, Lamana ML, Yañez RM, Casado JA, Giménez Y, Román-Rodríguez FJ, Álvarez L, Alberquilla O, Raimbault A, Guenechea G, Lozano ML, Cerrato L, Hernando M, Gálvez E, Hladun R, Giralt I, Barquinero J, Galy A, García de Andoín N, López R, Catalá A, Schwartz JD, Surrallés J, Soulier J, Schmidt M, Díaz de Heredia C, Sevilla J, Bueren JA.

Nature medicine Epub 2019 Sep 9. 2019 Sep;25(9):1396-1401.

PMID: 31501599

FI: 30,641


Low risk pragmatic trials do not always require participants' informed consent.

Dal-Ré R, Avendaño-Solà C, Bloechl-Daum B, de Boer A, Eriksson S, Fuhr U, Holm S, James SK, Mentz RJ, Perucca E, Rosendaal FR, Treweek S.

BMJ-British medical journal 2019 Mar 27;364:l1092.

PMID: 30917969

FI: 27,604


Association of Polyps with Early-Onset Colorectal Cancer and Throughout Surveillance: Novel Clinical and Molecular Implications.

Perea García J, Arribas J, Cañete Á, García JL, Álvaro E, Tapial S, Narváez C, Vivas A, Brandáriz L, Hernández-Villafranca S, Rueda D, Rodríguez Y, Pérez-García J, Olmedillas-López S, García-Olmo D, Cavestro GM, Urioste M, Goel A, González-Sarmiento R.

Cancers 2019 Nov 29;11(12). pii: E1900.

PMID: 31795313

FI: 6,162


Autologous adipose-derived stem cells for the treatment of complex cryptoglandular perianal fistula: A randomized clinical trial with long-term follow-up.

Garcia-Arranz M, Garcia-Olmo D, Herreros MD, Gracia-Solana J, Guadalajara H, De la Portilla F, Baixauli J, Garcia-Garcia J, Ramirez JM, Sanchez-Guijo F, Prosper F, FISPAC Collaborative Group.

Stem cells translational medicine 2019 Dec 30.

PMID: 31886629

FI: 5,962