Responsable

  • Juan Bueren (CIEMAT)

IPs

  • Marina Inmaculada Garín Ferreira
  • José Carlos Segovia Sanz
  • Rosa María Yáñez González

Investigación

  • Básica
  • Clínica

Producción científica


Resumen 2017


Nº total de publicaciones

Nº de publicaciones con FI

FI Acumulado

FI medio anual

Nº REVISTAS Q1

(%) Q1

16

15

84,78

5,65

10

66,67%


Publicaciones 2017


Engraftment and in vivo proliferation advantage of gene corrected mobilized CD34<sup>+</sup> cells from Fanconi anemia patients.

Río P, Navarro S, Guenechea G, Sánchez-Domínguez R, Lamana ML, Yañez R, Casado JA, Mehta PA, Pujol MR, Surrallés J, Charrier S, Galy A, Segovia JC, Díaz de Heredia C, Sevilla J, Bueren J.

Blood. 2017 Sep 28;130(13):1535-1542.

PMID: 28801449

FI: 13,164

BMP4 Induces M2 Macrophage Polarization and Favors Tumor Progression in Bladder Cancer.

Martínez VG, Rubio C, Martínez-Fernández M, Segovia C, López-Calderón F, Garín MI, Teijeira A, Munera-Maravilla E, Varas A, Sacedón R, Guerrero F, Villacampa F, de la Rosa F, Castellano D, López-Collazo E, Paramio JM, Vicente Á, Dueñas M.

Clinical cancer research : an official journal of the American Association for Cancer Research. 2017 Dec 1;23(23):7388-7399.

PMID: 28928159

FI: 9,619

Lessons Learned from Two Decades of Clinical Trial Experience in Gene Therapy for Fanconi Anemia.

Adair JE, Sevilla J, de Heredia CD, Becker PS, Kiem HP, Bueren J.

Current gene therapy. 2017;16(5):338-348.

PMID: 28103787

FI: 2,780

Therapeutic gene editing in CD34<sup>+</sup> hematopoietic progenitors from Fanconi anemia patients.

Diez B, Genovese P, Roman-Rodriguez FJ, Alvarez L, Schiroli G, Ugalde L, Rodriguez-Perales S, Sevilla J, Diaz de Heredia C, Holmes MC, Lombardo A, Naldini L, Bueren JA, Rio P.

EMBO molecular medicine. 2017 Nov;9(11):1574-1588.

PMID: 28899930

FI: 9,249

Intralymphatic Administration of Adipose Mesenchymal Stem Cells Reduces the Severity of Collagen-Induced Experimental Arthritis.

Mancheño-Corvo P, Lopez-Santalla M, Menta R, DelaRosa O, Mulero F, Del Rio B, Ramirez C, Büscher D, Bueren JA, Lopez-Belmonte J, Dalemans W, Garin MI, Lombardo E.

Frontiers in immunology 2017 Volume: 8 Issue: Pages: 462.

PMID: 28484460

FI: 6,429

Biodistribution and Efficacy of Human Adipose-Derived Mesenchymal Stem Cells Following Intranodal Administration in Experimental Colitis.

Lopez-Santalla M, Mancheño-Corvo P, Escolano A, Menta R, DelaRosa O, Abad JL, Büscher D, Redondo JM, Bueren JA, Dalemans W, Lombardo E, Garin MI.

Frontiers in immunology 2017 Volume: 8 Issue: Pages: 638.

PMID: 28642759

FI: 6,429

Worldwide study of hematopoietic allogeneic stem cell transplantation in pyruvate kinase deficiency.

van Straaten S, Bierings M, Bianchi P, Akiyoshi K, Kanno H, Badell Serra I, Chen J, Huang X, van Beers E, Ekwattanakit S, Güngör T, Kors WA, Smiers F, Raymakers R, Yanez L, Sevilla J, van Solinge W, Segovia JC, Van Wijk R.

Haematologica. 2017 Dec 14.

PMID: 29242305

FI: 7,702

A short and efficient transduction protocol of mouse hematopoietic stem cells with lentiviral vectors.

Fernandez-Garcia M, Mesa-Nuñez C, Almarza E, Bueren J, Yañez R.

Human gene therapy methods. 2017 Dec;28(6):310-317.

PMID: 28817977

FI: 1,831

Improved hematopoietic gene therapy in a mouse model of Fanconi anemia mediated by mesenchymal stromal cells.

Fernandez-Garcia M, Lamana Luzuriaga M, Hernando-Rodriguez M, Sanchez-Dominguez R, Bueren J, Yañez R.

Human gene therapy. 2017 Aug 17.

PMID: 28816065

FI: 4,187

Mutations in xlf/nhej1/cernunnos Gene Results In Downregulation of Telomerase Genes Expression and Telomere Shortening.

Carrillo J, Calvete O, Pintado Berninches L, Manguan-García C, Sevilla Navarro J, Arias-Salgado EG, Sastre L, Guenechea G, López Granados E, de Villartay JP, Revy P, Benitez J, Perona R.

Human molecular genetics. 2017 May 15;26(10):1900-1914.

PMID: 28369633

FI: 5,340

Highly efficient genome editing of human hematopoietic stem cells via a nano-silicon-blade delivery approach.

Ma Y, Han X, Quintana Bustamante O, Bessa de Castro R, Zhang K, Zhang P, Li Y, Liu Z, Liu X, Ferrari M, Hu Z, Carlos Segovia J, Qin L.

Integrative biology : quantitative biosciences from nano to macro. 2017 Jun 19;9(6):548-554.

PMID: 28513735

FI: 3,252

IKK?-Mediated Resistance to Skin Cancer Development Is <i>Ink4a/Arf-</i>Dependent.

Page A, Bravo A, Suarez-Cabrera C, Alameda JP, Casanova ML, Lorz C, Segrelles C, Segovia JC, Paramio JM, Navarro M, Ramirez A.

Molecular cancer research : MCR. 2017 Sep Volume: 15 Issue: 9 Pages: 1255-1264.

PMID: 28584022

FI: 4,974

In vivo imaging of lung inflammation with neutrophil-specific <sup>68</sup>Ga nano-radiotracer.

Pellico J, Lechuga-Vieco AV, Almarza E, Hidalgo A, Mesa-Nuñez C, Fernández-Barahona I, Quintana JA, Bueren J, Enríquez JA, Ruiz-Cabello J, Herranz F.

Scientific reports. 2017 Oct 16 Volume: 7 Issue: 1 Pages: 13242.

PMID: 29038592

FI: 4,259

Induced Pluripotency and Gene Editing in Fanconi Anemia

Navarro S, Giorgetti A, Raya A, Tolar J.

Current Gene Therapy 2017 Volume: 16 Issue: 5 Pages: 321-328.

PMID: 28103772

FI: 2,780

Measles virus envelope pseudotyped lentiviral vectors transduce quiescent human HSCs at an efficiency without precedent

Lévy C, Amirache F, Girard-Gagnepain A, Frecha C, Roman-Rodríguez FJ, Bernadin O, Costa C, Nègre D, Gutierrez-Guerrero A, Vranckx LS, Clerc I, Taylor N, Thielecke L, Cornils K, Bueren JA, Rio P, Gijsbers R, Cosset FL, Verhoeyen E.

Blood advances 2017 Oct 24 Volume: 1 Issue: 23 Pages: 2088-2104.

PMID: 29296856

FI: 0

Gene Therapy in Fanconi Anemia: A Matter of Time, Safety and Gene Transfer Tool Efficiency

Verhoeyen E, Roman-Rodriguez FJ, Cosset FL, Levy C, Rio P..

Curr Gene Ther 2017 Volume: 16 Issue: 5 Pages: 297-308.

PMID: 28067165

FI: 2,780



Proyectos, Contratos y EOs vigentes 2017


Fuentes de financiación públicas de proyectos que se están desarrollando en el IIS-FJD:

ImagenImagen




REFERENCIA

TÍTULO PROYECTO

INVESTIGADOR PRINCIPAL

GRUPO

TIPO DE PROYECTO

CB06/07/0014

GRUPO DE INVESTIGACION DEL CIBER DE ENFERMEDADES RARAS

BUEREN RONCERO JUAN ANTONIO

TERAPIAS AVANZADAS

PROYECTO FIS

RD16/0011/0011

RED DE TERAPIA CELULAR (TerCel)

SEGOVIA SANZ JOSE CARLOS

TERAPIAS AVANZADAS

REDES

CONV/CIEMAT01

ACUERDO ESPECÍFICO PARA LA CONSTITUCIÓN DE UNA UNIDAD MIXTA DE TERAPIAS AVANZADAS ENTRE EL CIEMAT Y EL INSTITUTO DE INVESTIGACIÓN SANITARIO DE LA FUNDACIÓN JIMÉNEZ DÍAZ

BUEREN RONCERO JUAN ANTONIO

TERAPIAS AVANZADAS

CONVENIO COLABORACIÓN