Carlos Blas López

Nucleic acid extraction, PCR, qPCR, digital PCR, fragment analysis, Sanger Sequencing and NGS (molecular biology) and HPLC and molecular studies in Eritopathology

Research:

• Codirector of final degree project : "Correlation between hematology laboratory parameters and genetic mutations in beta thalassemia. A study of 164 cases". D. Boianelli, Facultad de Medicina. Universidad Autónoma de Madrid, 2017

Taching:

• Teaching collaborator Universidad Autonoma de Madrid (UAM)
• Teaching collaborator Universidad Rey Juan Carlos (URJC)
• Teaching collaborator Universidad Alfonso X (UAX)
• Tutor of residents, Hematology Department, Fundación Jiménez Díaz (2012-2016)

1. Persistent polyclonal B-cell lymphocytosis in a middle-aged, smoking woman with typical morphologic and genetic hallmarks. PMID: 11532639
2. Deletion of sequences flanking the t (9; 22) breakpoint: a secondary genetic event associated with loss of cytogenetic response to interferon in a Philadelphia-positive chronic myeloid leukaemia patient. DOI: 10.1046/j.1365-2141.2002.03432.x
3. High molecular response rate and clinical correlation in patients with follicular lymphoma treated with cyclophosphamide-vincristine-prednisone plus interferon alpha 2b.
PMID: 12855623
4. The prevalence of hepatitis C virus infection in patients with non-Hodgkin's lymphoma. PMID: 15075985
5. Evaluation of CD7 and Terminal deoxynucleotidyl transferase (TdT) expression in CD34+ myeloblasts from patients with myelodysplastic syndrome. PMID: 16417922
6. Clonal evolution in patients with chronic lymphocytic leukemia. PMID: 20443678
7. Cut-off Values of Hematologic Parameters to Predict the Number of Alpha Genes Deleted in Subjects with Deletional Alpha Thalassemia doi: 10.3390/ijms18122707.
8. Comparison of Droplet Digital PCR versus qPCR Measurements on the International Scale for the Molecular Monitoring of Chronic Myeloid Leukemia Patients. Molecular Diagnosis & Therapy. 24, pp.593–600. doi: 10.1007/s40291-020-00485-4
9. Lymphoplasmacytic lymphoma associated with diffuse large B-cell lymphoma: Progression or divergent evolution? PMID: 3318088
10. Prognostic significance of FLT3-ITD length in AML patients treated with intensive regimens. Scientific Reports. 11-20745. doi: 10.1038/s41598-021-00050-x
11. ZBTB16-RARα-Positive Atypical Promyelocytic Leukemia: A Case Report
Medicina 2022, 58, 520. https://doi.org/10.3390/medicina58040520
12. Spontaneous Remission of Acute Myeloid Leukemia: A Case Report Medicina. 2022; 58(7):921. doi:10.3390/medicina58070921
13. Spontaneous Remission of Blastic Plasmacytoid Dendritic Cell Neoplasm: A Case Report. Medicina. doi: 10.3390/medicina60050807.
14. No evidence that CD33 rs12459419 polymorphism predicts gemtuzumab ozogamicin response in consolidation treatment of acute myeloid leukemia patients: experience of the PETHEMA group. Disease Markers. 2022. doi: 10.1155/2022/3132941.
15. Flow Cytometry Analysis of Mesenchymal Stem Cells: A Predictive Biomarker for Leukemia Transformation in Myelodysplastic Syndrome. eJHaem 2025 doi.org/10.1002/jha2.70059
16. Tratamiento de los linfomas indolentes. En "Terapia en Oncohematología", Hartcourt Brace 1998.
17. - Hemocromatosis. Monografía XX ("Enfermedades metabólicas") de la Real Academia Nacional de Farmacia, 2006.
-Hemocromatosis. Manual práctico de genética hematológica (2016). ISBN 978-84-608-1494-8

• Oral comunication: " High molecular response rate in patients with low grade non hodgkin´s lymphoma treated with cvp and interferon alfa 2b"). 2000 Anual Meeting of the American Society of Hematology, San Francisco.
• Talk:" Treatment of iron deficiency anemia. Iron preparations. Selection criteria" III Course on Rational Use of Medication, organized by the General Directorate of Primary Care of Area 2 (January 1997)).
• Talk: Diploma Course in Occupational Nursing at the National School of Occupational Medicine (June 1997)
• Talk: Applications of Molecular Biology to the Diagnosis of Non-Neoplastic Hematological Diseases. Doctoral Course F. of Medicine UAM (2003).
• Talk: Hemochromatosis: Epidemiology, Clinical Features, and Treatment. Refresher Course in Hematology . Clínica Moncloa. 2005. Spain
• Talk: Applications of Molecular Biology to Clinical Practice in Hematology. Refresher Course in Hematology . Clínica Moncloa. 2005. Spain
• Talk: 1st CML Update Conference . 2011. Spain
• Talk: 2nd CML Update Conference . 2012. Spain
• Talk : Diagnostic and therapeutic update in AML: Detection of measurable residual disease in AML . 2023. Spain